Rome started working professionally as an actress in the late 1960s. In addition to her work on The Pumaman she is also known for her work on the 1972 film What? and the 1981 film Looping. Rome recently acquired the rights to Whatever Happened to Baby Jane and had created a stage presentation based on that story. Her production enjoyed a successful run in Rome, Italy in 2013 and she plans to continue running it in Italy.
Rome's first husband was Emilio Lari, who was a crew member on The Pumaman as well as Ladyhawke and Francis Ford Coppola's The Godfather Part III. In 1987 Rome married Roberto Bernabei and has had two children with him.