The devious Dr. Acula poses as a medium who can communicate with the dead in order to trick their mourning relatives out of money. Acula accidentally succeeds in raising the dead, with horrific consequences.
- A psuedo-sequel to 1956's Bride of the Monster, Night of Ghouls features some of the same cast (from the usual Ed Wood stable of actors), in some cases reprising the same role (such as Tor Johnson as Lobo and Paul Marco as Kelton).
- Night of the Ghouls includes framing sequences with Criswell, in much the same way that Plan 9 from Outer Space did.
- As of May 2017, Night of the Ghouls has not been used by Mystery Science Theater 3000 or any of its corollary productions (Rifftrax, Cinematic Titanic, etc.)