Currently Frank works as a successful stand up comedian. He produced a long-running live comedy show in Los Angeles called "Cartoon Dump". Frank is also a member of the crew of Cinematic Titanic, riffing on bad movies alongside fellow MST3K alumni.
In 2011, Conniff appeared in the satirical dark comedy God Bless America. Conniff also wrote and performed satirical bits for the second and final season of FX Network's political sketch show "Totally Biased with W. Kamau Bell". Like Michael J. Nelson and Co., Conniff also frequently provides witty comments on his Twitter and FaceBook page.